The Key to Cryptography: The RSA Algorithm

Cryptography is the study of codes, as well as the art of writing and solving them. It has been a growing area of study for the past 40 years. Now that most information is sent and received through the internet, people need ways to protect what they send. Some of the most commonly used cryptosystems today include a public key. Some public keys are based around using two large, random prime numbers combined together to help encrypt messages. The purpose of this project was to test the strength of the RSA cryptosystem public key. This public key is created by taking the product of two large prime numbers. We needed to find a way to factor this number and see how long it would take to factor it. So we coded several factoring algorithms to test this. The algorithms that were implemented to factor are Trial Division, Pollard’s Rho, and the Quadratic Sieve. Using these algorithms we were able to find the threshold for decrypting large prime numbers used in Cryptography

Narrowband Interference Detection via Deep Learning

Due to the increased usage of spectrum caused by the exponential growth of wireless devices, detecting and avoiding interference has become an increasingly relevant problem to ensure uninterrupted wireless communications. In this paper, we focus our interest on detecting narrowband interference caused by signals that despite occupying a small portion of the spectrum only can cause significant harm to wireless systems, for example, in the case of interference with pilots and other signals that are used to equalize the effect of the channel or attain synchronization. Due to the small sizes of these signals, detection can be difficult due to their low energy footprint, while greatly impacting (or denying completely in some cases) network communications. We present a novel narrowband interference detection solution that utilizes convolutional neural networks (CNNs) to detect and locate these signals with high accuracy. To demonstrate the effectiveness of our solution, we have built a prototype that has been tested and validated on a real-world over-the-air large-scale wireless testbed. Our experimental results show that our solution is capable of detecting narrowband jamming attacks with an accuracy of up to 99%. Moreover, it is also able to detect multiple attacks affecting several frequencies at the same time even in the case of previously unseen attack patterns. Not only can our solution achieve a detection accuracy between 92% and 99%, but it does so by only adding an inference latency of 0.093ms.Comment: 6 pages, 10 figures, 1 table. ICC 2023 - IEEE International Conference on Communications, Rome, Italy, May 202

Colosseum as a Digital Twin: Bridging Real-World Experimentation and Wireless Network Emulation

Wireless network emulators are being increasingly used for developing and evaluating new solutions for Next Generation (NextG) wireless networks. However, the reliability of the solutions tested on emulation platforms heavily depends on the precision of the emulation process, model design, and parameter settings. To address, obviate or minimize the impact of errors of emulation models, in this work we apply the concept of Digital Twin (DT) to large-scale wireless systems. Specifically, we demonstrate the use of Colosseum, the world's largest wireless network emulator with hardware-in-the-loop, as a DT for NextG experimental wireless research at scale. As proof of concept, we leverage the Channel emulation scenario generator and Sounder Toolchain (CaST) to create the DT of a publicly-available over-the-air indoor testbed for sub-6 GHz research, namely, Arena. Then, we validate the Colosseum DT through experimental campaigns on emulated wireless environments, including scenarios concerning cellular networks and jamming of Wi-Fi nodes, on both the real and digital systems. Our experiments show that the DT is able to provide a faithful representation of the real-world setup, obtaining an average accuracy of up to 92.5% in throughput and 80% in Signal to Interference plus Noise Ratio (SINR).Comment: 15 pages, 21 figures, 1 tabl

ESWORD: Implementation of Wireless Jamming Attacks in a Real-World Emulated Network

Wireless jamming attacks have plagued wireless communication systems and will continue to do so going forward with technological advances. These attacks fall under the category of Electronic Warfare (EW), a continuously growing area in both attack and defense of the electromagnetic spectrum, with one subcategory being electronic attacks. Jamming attacks fall under this specific subcategory of EW as they comprise adversarial signals that attempt to disrupt, deny, degrade, destroy, or deceive legitimate signals in the electromagnetic spectrum. While jamming is not going away, recent research advances have started to get the upper hand against these attacks by leveraging new methods and techniques, such as machine learning. However, testing such jamming solutions on a wide and realistic scale is a daunting task due to strict regulations on spectrum emissions. In this paper, we introduce eSWORD, the first large-scale framework that allows users to safely conduct real-time and controlled jamming experiments with hardware-in-the-loop. This is done by integrating eSWORD into the Colosseum wireless network emulator that enables large-scale experiments with up to 50 software-defined radio nodes. We compare the performance of eSWORD with that of real-world jamming systems by using an over-the-air wireless testbed (ensuring safe measures were taken when conducting experiments). Our experimental results demonstrate that eSWORD follows similar patterns in throughput, signal-to-noise ratio, and link status to real-world jamming experiments, testifying to the high accuracy of the emulated eSWORD setup.Comment: 6 pages, 7 figures, 1 table. IEEE Wireless Communications and Networking Conference (WCNC), Glasgow, Scotland, March 202

A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing

Transcriptomics (at the level of single cells, tissues and/or whole organisms) underpins many fields of biomedical science, from understanding the basic cellular function in model organisms, to the elucidation of the biological events that govern the development and progression of human diseases, and the exploration of the mechanisms of survival, drug-resistance and virulence of pathogens. Next-generation sequencing (NGS) technologies are contributing to a massive expansion of transcriptomics in all fields and are reducing the cost, time and performance barriers presented by conventional approaches. However, bioinformatic tools for the analysis of the sequence data sets produced by these technologies can be daunting to researchers with limited or no expertise in bioinformatics. Here, we constructed a semi-automated, bioinformatic workflow system, and critically evaluated it for the analysis and annotation of large-scale sequence data sets generated by NGS. We demonstrated its utility for the exploration of differences in the transcriptomes among various stages and both sexes of an economically important parasitic worm (Oesophagostomum dentatum) as well as the prediction and prioritization of essential molecules (including GTPases, protein kinases and phosphatases) as novel drug target candidates. This workflow system provides a practical tool for the assembly, annotation and analysis of NGS data sets, also to researchers with a limited bioinformatic expertise. The custom-written Perl, Python and Unix shell computer scripts used can be readily modified or adapted to suit many different applications. This system is now utilized routinely for the analysis of data sets from pathogens of major socio-economic importance and can, in principle, be applied to transcriptomics data sets from any organism

A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing

Transcriptomics (at the level of single cells, tissues and/or whole organisms) underpins many fields of biomedical science, from understanding the basic cellular function in model organisms, to the elucidation of the biological events that govern the development and progression of human diseases, and the exploration of the mechanisms of survival, drug-resistance and virulence of pathogens. Next-generation sequencing (NGS) technologies are contributing to a massive expansion of transcriptomics in all fields and are reducing the cost, time and performance barriers presented by conventional approaches. However, bioinformatic tools for the analysis of the sequence data sets produced by these technologies can be daunting to researchers with limited or no expertise in bioinformatics. Here, we constructed a semi-automated, bioinformatic workflow system, and critically evaluated it for the analysis and annotation of large-scale sequence data sets generated by NGS. We demonstrated its utility for the exploration of differences in the transcriptomes among various stages and both sexes of an economically important parasitic worm (Oesophagostomum dentatum) as well as the prediction and prioritization of essential molecules (including GTPases, protein kinases and phosphatases) as novel drug target candidates. This workflow system provides a practical tool for the assembly, annotation and analysis of NGS data sets, also to researchers with a limited bioinformatic expertise. The custom-written Perl, Python and Unix shell computer scripts used can be readily modified or adapted to suit many different applications. This system is now utilized routinely for the analysis of data sets from pathogens of major socio-economic importance and can, in principle, be applied to transcriptomics data sets from any organism

Progress in upscaling Miscanthus biomass production for the European bio-economy with seed-based hybrids

Funded by UK's Biotechnology and Biological Sciences Research Council (BBSRC) Department for Environment, Food and Rural Affairs (DEFRA). Grant Number: LK0863 BBSRC strategic programme Grant on Energy Grasses & Bio-refining. Grant Number: BBS/E/W/10963A01 OPTIMISC. Grant Number: FP7-289159 WATBIO. Grant Number: FP7-311929 Innovate UK/BBSRC ‘MUST’. Grant Number: BB/N016149/1Peer reviewedPublisher PD

Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits

Background Over the last several years, it has become apparent that there are critical problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational characteristics of natural stimuli such as food. Hypotheses related to DA function are undergoing a substantial restructuring, such that the classic emphasis on hedonia and primary reward is giving way to diverse lines of research that focus on aspects of instrumental learning, reward prediction, incentive motivation, and behavioral activation. Objective The present review discusses dopaminergic involvement in behavioral activation and, in particular, emphasizes the effort-related functions of nucleus accumbens DA and associated forebrain circuitry. Results The effects of accumbens DA depletions on food-seeking behavior are critically dependent upon the work requirements of the task. Lever pressing schedules that have minimal work requirements are largely unaffected by accumbens DA depletions, whereas reinforcement schedules that have high work (e.g., ratio) requirements are substantially impaired by accumbens DA depletions. Moreover, interference with accumbens DA transmission exerts a powerful influence over effort-related decision making. Rats with accumbens DA depletions reallocate their instrumental behavior away from food-reinforced tasks that have high response requirements, and instead, these rats select a less-effortful type of food-seeking behavior. Conclusions Along with prefrontal cortex and the amygdala, nucleus accumbens is a component of the brain circuitry regulating effort-related functions. Studies of the brain systems regulating effort-based processes may have implications for understanding drug abuse, as well as energy-related disorders such as psychomotor slowing, fatigue, or anergia in depression

Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility

Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead